Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.
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Parts of this study were presented in abstract form at Experimental BiologyFrucctose, Massachusetts, 20—24 April No other potential conflicts of interest relevant to this article were reported.
The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake. These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate. Author hypruricemia Copyright and License information Disclaimer. The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0.
Published online Aug As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance. After the infusion of fructose, 0. Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries.
Support Center Support Center. In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose. Although the cumulative fructose load was large 1. Open in a separate window. Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1. Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.
Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change. Am J Clin Nutr ; National Center for Biotechnology InformationU. In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.
These samples were collected while subjects were participating in two clinical trials clinical trial reg. Closed symbols represent data collected after 4—6 days of HFrD.
Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal onduced of the metabolic syndrome. This article has hyperuricenia cited by other articles in PMC. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose.
These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia.
Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: In addition, we observed that a serum uric acid level above 5. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition.
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This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co. Fructose–unlike fructise sugars–causes serum uric acid levels to rise rapidly. This effect appears to be specific for fructose. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.
It has not been assessed, however, whether UA also increases when fructose is administered onduced several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.
Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Journal List Diabetes Care v.
Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.
NO increases blood flow to skeletal muscle and enhances glucose uptake.